SYNTHESIS AND ANTICONVULSANT ACTIVITY OF N-SUBSTITUTED-7-HYDROXY-4-METHYL-2-OXA-QUINOLINE DERIVATIVES

The reaction of resorcinol with ethyl acetoacetate yielded the 7-hydroxy-4-methyl coumarin, which on treatment with substituted thiadiazole in presence of glacial acetic acid gives 7-hydroxy-4-methyl-1-5-phenyl-1,3,4-thiadiazole-2yl,qinoline-2(1H)-one. Purity of synthesized compound was checked by TLC and structures were elucidated by their IR, 1H NMR and elemental analysis data. The synthesized compounds were screened for anticonvulsant activity. Keywords Quinoline-2(1H)-one derivative, Resorcinol, Glacial acetic acid, Anticonvulsant activity.