Clinical observation of Lrh-BNP on treating acute myocardial infarction complicating heart failure

Objective To observe the clinical effect of lyophilized recombinant human brain natriuretic peptide(LrhBNP) on treating acute myocardial infarction complicating heart failure.Methods Selected 100 cases of patients with ST elevation acute myocardial infarction complicating heart failure in our hospital from December 2010 to December 2012,according to the proportion of 1 ∶1 were divided into observation group(group A) and control group(group B).The control group were treated with routine treatment,while the observation group were treated with Lrh-BNP on the basis of routine treatment.Carefully observed the breathing difficulties,heart function classification and evaluation of heart doppler ultrasound when they left the hospital of the two groups.Results The improvement rate of breathing difficulties in observation group was 90%,while the control group was 54%;the improvement of heart function classifica tion in observation group was 96%,while the control group was 58%;obviously the observation group were superior to control group,and the differences were statistical significant(P 0.05).In the comparison of LV size evaluated by heart doppler ultrasound when the patients left hospital,observation group was superior to control group,and the dif ference was statistical significant(P 0.05);in the comparison of variation of ECG,there was no significant difference between the two groups(P 0.05).Conclusion Lrh-BNP can obviously improve clinical symptoms in the treatment of acute myocardial infarction complicating heart failure,and worthy of clinical application.