Increased Expression of Fractalkine is Correlated with a Better Prognosis and an Increased Number of Both CD8 + T Cells and Natural Killer Cells in Gastric Adenocarcinoma

Background Fractalkine (CX3CL1) is the only CX3C chemokine that can chemoattract natural killer (NK) cells, CD8+ T cells, monocytes, and dendritic cells. Although experimental studies have demonstrated that Fractalkine expression by tumor cells is related to the infiltrating lymphocytes and initiates antitumor immunity, the clinical significance of Fractalkine remains to be elucidated in gastric adenocarcinoma.