A Meta-analysis of Risk Factors for Gliomas and Incidence Change after Controlling Risk Factors

Objective To systematically analyze the risk factors for gliomas and evaluate the tendency of incidence change after controlling those risk factors in order to provide evidence for primary prevention of the disease.Methods Case-control studies on risk factors of brain gliomas were collected and screened for the main risk factor.Meta analysis was used to calculate the overall odds ratio(OR) and 95% confidence intervals for each selected factor.Then,we estimated population attributable risk proportion(PARP) and evaluated the tendency of incidence change after controlling risk factors.Results Thirteen articles on risk factors of glioma were selected.The first 5 risk factors were Plumbum exposure(OR=7.060),gasoline exposure(OR=3.242),heavy or prolonged smoking(OR=2.960),family history of tumor(OR=2.612),and frequent intake of toasted or cured food(OR=2.544).The factors for high PARP were heavy or prolonged smoking(30.979%),frequent intake of toasted or cured food(27.713%),rays or electromagnetic field exposure(23.964%),and gasoline exposure(13.799%).If the exposure rates of these risk factors decrease by 25% and 50% in the near future,the incidence of glioma would reduce by 7.745%,5.937%,5.991%,3.450% and 15.490%,11.875%,11.982%,6.900% respectively.Conclusion Unhealthy living habits and occupational hazards are closely related to glioma incidence.Effective preventive measures related to these risk factors should be conducted to control the onset and development of glioma.