Alkaline antibacterial peptide as well as targeting design and application thereof

2015 
The invention belongs to the field of biotechnology, and discloses an alkaline antibacterial peptide as well as targeting design and application thereof. The alkaline antibacterial peptide is composed of at least one alkaline amino acid and one or two hydrophobic amino acids; the alkaline antibacterial peptide includes 12-24 amino acids, wherein the proportion of the alkaline antibacterial peptide is more than 33.3%, and the alkaline antibacterial peptide has a broad-spectrum bacteriostatic action on escherichia coli, pseudomonas aeruginosa, staphylococcus aureus, multi-drug resistance staphylococcus aureus, saccharomyces cerevisiae and the like; the alkaline antibacterial peptide is prepared as a targeted antibacterial peptide, and the efficiency of the antibacterial peptide in killing lung cancer cells at 0.1mM reaches 100.3%; the antibacterial peptide or the targeted antibacterial peptide disclosed by the invention is applicable to bacterium inhabitation and cancer resistance, and can be widely applied to the fields of medicine, agriculture, food preservative and the like.
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