Phospholipid protein particle composite microsphere and preparation method thereof

The invention relates to a phospholipid protein particle composite microsphere and a preparation method thereof. The preparation method comprises the following steps: stirring and mixing protein or polypeptide water-soluble drugs, an aqueous solution of a freeze-drying protective additive and an alcoholic solution of phospholipid to obtain a lipid vesicle suspension of phospholipid protein; freeze-drying for removing the solvent to obtain phospholipid protein particles; uniformly dispersing the phospholipid protein particles into an organic solution of a polymer carrier material, then adding an aqueous solution containing an emulsifying agent, and shearing at a high speed to prepare emulsion of S/O/W; and carrying out the processes of solvent volatilization, microsphere curing and the like to form the phospholipid protein particle composite microsphere. The phospholipid protein particle composite microsphere prepared by the method provided by the invention has a high drug envelopment rate and a low sudden release rate, wherein the release rate at the first day is 9-15%; the release rate is stable and lasting, the slow release period of the preparation can reach 20-60 days, and the bioactivity of the drugs in the microsphere is high; and therefore, the phospholipid protein particle composite microsphere has practical values in clinical application.