A Clinicopathologic Study of Primary Small Cell Carcinoma of the Uterine Cervix

[Objective] To study the clinicopathological characterises of small cell carcinoma of the cervix(SCCC) and the factors for prognosis.[Method] We collected all the cases of cervical carcinoma during 1996 and 2008.Among these,there were 25 cases of SCCC,and 24 cases were confirmed as SCCC with complete data.Patients' age,presenting symptoms,disease stage,tumour size,treatment and follow-up were reported.Histological features were observed and immunohistochemical detection of cytokeratin(CK),epithelial membrane antigen(EMA),neuron specific enolase(NSE),synaptophysin(Syn),chromogranin A(CgA),neuronal cell adhesion molecules(CD56),thyroid transcriptional factor-1(TTF-1) and S100 protein(S100) was performed.[Result] The median age of patients in this study was 44.8 years old.The median patient survival time was 19.2 months after diagnosis.Histologically,there were 18 homogenous SCCC samples and 6 samples comprised of SCCC and other histological categories.The percentages of SCCC with positive immunoreactivity were,NSE 100.0%,Syn 95.8%,CD56 66.7%,CgA 79.2%,TTF-1 37.5%,EMA 83.3%,CK 66.7%,and S100 8.3%.[Conclusion] SCCC was a kind of malignant tumour on cervical epithelium.It was rare,aggressive and with poor prognosis.The main treatment was operation,assisted with other methods.Pathological study showed high proportion of positive labelling of NSE,Syn,CD56 and CgA.Combinate detection of these four markers would be valuable for diagnosis.