Pharmaceutical Study of Additional Erzhi Grains

Objective: To explore the extraction and moulding technology of Additional Erzhi Grains. Methods: By investigating the single factors of the concentration of ethanol,ethanol consumption,extraction time and extraction temperature,we determined the best conditions. In order to optimize the extraction technology,use orthogonal table L9( 34) to arrange the experiment with the content of glossy privet fruit glucosides and as the evaluation index. By comparing the impact of differences in materials with the grains,we determined the best material combination,inspected the liquidity of the grains by determining the angle of repose and determined the critical relative humidity( CRH). Results: The extraction technology of additional erzhi grains was as follows: 15 times volume 60% ethanol,3 h reflux extraction at 100 ℃. The best moulding technology of Additional Erzhi Grains was as follows: 2. 5 times of auxiliary materials( lactose ∶ CMC- Na = 9 ∶ 1). Its fluidity was good and the critical relative humidity was 66%. The Additional Erzhi Grains were compliance to requirements of the quality requirements of grains in pharmacopoeia. Conclusion: The experiment showed that extraction process was not only stable,reasonable,simple,but also suitable for actual production. The appearance of the grains which were gained by the selected process was good,and the loss was relatively small in the granulating process. More over,the grains were quite uniformed.