[Effects of slenderstyle Acanthopanax root-bark on cyclooxygenase].

Objective: To explore the effects of slenderstyle acanthopanax root-bark on cyclooxygenase in vivo and in vitro.Method:Contents of 6-keto-PGF_(1α) in bovine aorta endothelial cells,PGE_2 in mouse abdominal macrophages,and 6-keto-PGF_(1α) in rat stomach tissue were determined.The ulcer index in rat gastric mucosa was measured.Result: COX-1 and COX-2 were inhibited by slenderstyle acanthopanax root-bark,and the inhibitive rate of COX-2 was higher than that of COX-1 at the same concentration. Necrotic injuries in health gastric mucosa were not produced,but the injuries previously induced by the ethanol worsened.Conclusion: One of the antirheumatic mechanisms of slenderstyle acanthopanax root-bark might probably be mediating through inhibition of cyclooxygenase.