Corticosteroid Administration Is Associated With Improved Outcome in Patients With Severe Acute Respiratory Syndrome Coronavirus 2-Related Acute Respiratory Distress Syndrome

Objectives: To compare the clinical outcome of mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome, who received corticosteroid with those who did not Design: Retrospective analysis Setting: Intensive care setting Patients: All adult mechanically ventilated patients, who were admitted to the ICU between March 20, 2020, and May 10, 2020, for severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome Interventions: None Measurements and Main Results: Cohort was divided into two groups based on corticosteroid administration The primary outcome variable was ventilator-free days at day 28 Secondary outcome variable was ICU-free days at day 30, and hospital-free days at day 30 Consecutive 61 mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome were analyzed Patient in corticosteroid group as compared with noncorticosteroid group have higher 28-day ventilator-free days (mean, 10 2;median, 7 [interquartile range, 0�22 3] vs mean, 4 7;median, 0 [interquartile range, 0�11];p = 0 01) There was no significant difference noted in secondary outcomes (ICU-free days at day 30 and hospital-free days at day 30) Conclusions: Among mechanically ventilated severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome patients, corticosteroids use was associated with significant improvement in 28-day ventilator-free days at day 28, but no significant improvement in ICU-free days at day 30, and hospital-free days at day 30