Cyclic, Cell-Penetrating Peptides Tailor-Made for the Creation of Peptide Libraries with Intrinsic Cell Permeability
2020
The discovery of high-affinity peptides to many
intracellular targets has become feasible
through the development of diverse macrocyclic peptide libraries. But lack of
cell permeability is a key feature
hampering the use of these peptides as therapeutics. Here, we develop a set of
small, cyclic peptide carriers that efficiently carry cargoes into the cytosol.
These peptides are cyclized via side-chain alkylation, which makes them ideal for the creation of
diverse mRNA or phage-displayed libraries with intrinsic cell permeability.
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