Adaptive changes in enteric explants instead of the urinary bladder

: One hundred and twenty-two biopsy specimens of enteric explants (orthotopic urinary reservoirs (OUR)) placed instead of the neoplastic urinary bladder were studied in 94 patients. The OUR wall changes were shown to be compensatory and adaptive and to appear as: (1) progressive atrophy and a reduction in enteric villae; brush-border enterocyte replacement by goblet cells secreting syalomucins with the appearance of the lining devoid of the brush border and secretion; (2) preservation of crypts as active regeneration areas with varying reductions, prevalence of goblet cell differentiation; and preservation of programmed differentiation; (3) adaptive muscular layer hypertrophy; (4) no morphological manifestations of both hyperplasia and dysplasia of the surface and crypt epithelium; (5) no morphological signs of destructive inflammation and sclerosis deformans.