HLA-DR3 and DR4 Allele Segregation in IDDM Families and in Controls

Segregation distortion of HLA alleles in IDDM families is still a matter of discussion. Some evidence for preferential transmission of DR3 and DR4 from parents to both diabetic and non-diabetic progenies has been given.1 However, other studies investigating the same issue have not confirmed this differential mode of inheritance.2