2-alkyl-or-aryl-substituted tanshinone derivatives, and preparation method and application thereof

The present invention relates to the field of natural drugs and pharmaceutical chemistry, and more particularly to novel 2-alkyl-or-aryl-substituted tanshinone I derivatives of a general formula I or pharmaceutically acceptable salts thereof, a method for preparing such compounds, a pharmaceutical composition containing the compound, and a use thereof in preparation of antitumor drugs. When Z=R, the derivative is 2-alkyl-substituted tanshinone I. When Z=Ar, the derivative is 2-aryl-substituted tanshinone I. When Z=Het, the derivative is 2-heteroaryl-or-heterocyclyl-substituted tanshinone I.