A New Platinum Anticancer Drug Forms a Highly Stereoselective Adduct with Duplex DNA

The alignment of the 2-picoline ligand within the major groove contributes to the formation of a highly stereoselective GG intrastrand bischelate between the new anticancer drug cis-[PtCl2(NH3)(2-picoline)] and a 14-mer DNA duplex (see schematic representation).