INHIBITORY ACTIVITY OF PROTECTED EDIBLE PLANTS ON OXIDATIVE STRESS INDUCED BY ORAL 1,4-DIOXANE.

Dioxane (DX) withtwo oxygen atoms make it hydrophilic and infinitely soluble in water. As a synthetic organic compound, it used widely throughout industry as a solvent. Dioxane cau s- es numerous human ailments such as liver damage and kidney failure. It has been shown in r e- search to be carcinogenic to animals, and is a potential carcinogen to humans. Daily administr a- tion for 1,4 -dioxane (100 mg/kg body weight) in drinking water for rats weighing 120 g, except for normal control group. Experimental animal for 42 days was foll owed through body weight, serum alkaline phosphatase, serum creatinine, malondialdehyde, and catalase enzyme activity; beside histological patterns for liver, kidney, brain and ovary sections. Protection treatment has been offered using oral i njection N -acetyl cysteine (100 mg/kg b.wt.), and fresh 200 mg/kg b.wt. in diet meal for each of nabk, husk, and sycamorein separated groups. Body weight and CAT a c- tivity have decreased by 25.8, and 68.7%, respectively. While increase has found in MDA, ALP and creatinin e values by 76, 48.9, and 67.3%, respectively. NAC showed improvement especially for MDA peroxidation marker and creatinine for kidney disorder. On the other hand, nabk improved CAT activity and husk for ALP liver mutagenicity marker. Intoxicated DXshowed edema, kupffer cell activation, atrophy of glomerular tuft, and necrosis of neurons in liver, kidney and brain sections. Obviously nabk showed highly improvement in liver toxicity which is the most sensitive organ to DX as found in research. Keyword s:Dioxane,Malondialdehyde,Catalase, Acetyl cysteine , Nabk, Husk, Sycamore.