Effect of Prostaglandin E1 On Rat's Antral Myoelectric Activity

The effect of abdomnoinjection prostaglandin E[1](PGE[1]) on antral myoelectric activity was investigated in 30 Wistar rats chronically implanted with Ag/AgCl bipolar electrode on the serosal surface of antrum.It was found that PGE[1] could 1) decrease the amplitude of slow wave;2) cause biphasic changes of fast wave,usually with enhancement before giving way to inhibition;3) cause diarrhea.The inhibitory action of PGE[1] on slow wave and fast wave might be not mediated via adrenergic α and β receptor,and the excitatory action of PGE[1] on fast wave was probably mediated via cholinergic M receptor.