1982年タイ国チェンマイ地区における脳炎のウィルス学的疫学的調査. : IV.入院患者の血清学的検査

One-hundred and eight paired sera including 40 encephalitis and 54 dengue hemorrhagic fever(DHF), and 71 single sera including 15 encephalitis and 25 DHF cases, were examined by the hemagglutination-inhibition (HI) against Japanese encephalitis (JE) and dengue antigens, as well as by the enzyme-linked immunosorbent assay(ELISA) against JE antigen. By the HI test, 10 encephalitis and 3 DHF cases showed primary type antibody response, while there were 7 encephalitis and 28 DHF with secondary responses. Only 7 encephalitis and 10 DHF cases with paired sera showed monospecific HI antibody reponse to JE and dengue antigens, respectively, and there were 7 encephalitis cases with monospecific HI antibody response to dengue antigens. IgM-ELISA against JE antigen appeared to be a more specific indicator of recent infection by JE virus, and could detect 27 positive cases. Twenty two of them were the cases with paired sera and 16 of them did not give positive and monospecific HI antibody response to JE antigen. Remaining 5 case were with single serum specimen. Serological tests suggested that at least 4 encephalitis case were due to dengue virus infections.