Targeting multiple epitopes on the spike protein: a new hope for COVID-19 antibody therapy.

Liu, L. et al. Potent neutralizing antibodies directed to multiple epitopes on SARS-CoV-2 spike. Nature https://doi.org/10.1038/s41586-020-2571-7 (2020). Lv, Z. et al. Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody. Science https://doi.org/10.1126/science.abc5881 (2020). Shi, R. et al. A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2. Nature https://doi.org/10.1038/s41586-020-2381-y (2020). Wu, Y. et al. A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2. Science 368, 1274–1278 (2020). CAS Article Google Scholar Baum, A. et al. Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies. Science https://doi.org/10.1126/science.abd0831 (2020). Download references This work was supported by the Strategic Priority Research Program of CAS (XDB37030204), the National Key Research and Development Program of China (2016YFD0500305), and the Zhejiang University Special Scientific Research Fund for COVID-19 Prevention and Control (2020XGZX031). CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 100101, Beijing, China Yeping Sun & Jianxun Qi School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD, 4072, Australia Bostjan Kobe Savaid Medical School, University of the Chinese Academy of Sciences, 100049, Beijing, China Jianxun Qi You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar Correspondence to Bostjan Kobe or Jianxun Qi. The authors declare no competing interests. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Reprints and Permissions Sun, Y., Kobe, B. & Qi, J. Targeting multiple epitopes on the spike protein: a new hope for COVID-19 antibody therapy. Sig Transduct Target Ther 5, 208 (2020). https://doi.org/10.1038/s41392-020-00320-6 Download citation Received: 10 August 2020 Revised: 25 August 2020 Accepted: 02 September 2020 Published: 19 September 2020 DOI: https://doi.org/10.1038/s41392-020-00320-6