GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.

Linda Yang,Chihchuan Chang,Zhe Sun,Dennis Madsen,Haisun Zhu,Søren Berg Padkjær,Xiaoai Wu,Tao Huang,Karin Hultman,Sarah Juel Paulsen,Jishu Wang,Anne Bugge,Jane Boesen Frantzen,Per Nørgaard,Jacob Jeppesen,Zhiru Yang,Anna Secher,Haibin Chen,Xun Li,Linu Mary John,Bing Shan,Zhenhua He,Xiang Gao,Jing Su,Kristian T Hansen,Wei Yang,Sebastian B. Jørgensen

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.

2017

GDF15 has potent anti-obesity effects, but its receptor was unknown. GFRAL has now been identified as the receptor that mediates GDF15's effects via central actions in the hindbrain.

Keywords:

Obesity
Immunology
Hindbrain
GDF15
Endocrinology
Receptor
Internal medicine
Biology
sprague dawley
HEK 293 cells
Flow cytometry
Ligand
anti obesity

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