Trattamento farmacologico a breve e lungo termine nelle sindromi depressive: focus sulla tollerabilità degli antidepressivi

Summary Objective Long-term treatment with antidepressants prevents relapses and recurrences of major depressive disorders and favours functional recovery. However, antidepressant side effects other than affect patient's health, may limit treatment adherence and social functioning. Most studies concerning antidepressant treatment have focused on short- term tolerability, less attention has been devoted to side effects that are reported during long-term. Method Medline databases were searched for existing studies on side effects and tolerability of long-term antidepressant treatment. Manual search on significant book chapters and reviews on the same topic has been also performed.