One-pot synthesis of 2,4,5-triaryl-1H-imidazoles linked 1,4-disubstituted 1,2,3-triazoles based on a merging multicomponent condensation with Huisgen 1,3-dipolar cycloaddition in ionic liquid

A new and efficient approach for the synthesis of 2,4,5-triaryl-1H-imidazoles linked 1,4-disubstitued 1,2,3-triazoles have been developed by multicomponent condensation with Huisgen 1,3-dipolar cycloaddition. A mixture of aromatic propargylated aldehydes, different azides, benzil, and ammonium acetate were condensed in the presence of catalytic amounts of acidic ionic liquid, 1-methylimidazolium trifluoroacetate, ([Hmim]TFA), and Cu(OAc)2/sodium ascorbate to afford the corresponding products. The features of this procedure are operational simplicity, good yields of products, and solvent-free conditions.