Seasonal changes in the physiological features of healthy and sensitive skin.

BACKGROUND The effects of seasonal factors on sensitive skin (SS) have been reported intensively, but the mechanisms still remain poorly understood. OBJECTIVE To investigate the effects of seasonal factors on SS, by comparing the physiological changes in the healthy skin and different subgroups of SS with seasonal variation. METHODS Through a questionnaire survey, lactic acid sting test, and capsaicin test, qualified subjects were classified into four groups: healthy skin, only lactic acid sting test positive (LAST(+)/CAT(-)), only capsaicin test positive (LAST(-)/CAT(+)), and both positive (LAST(+)/CAT(+)). Skin physiological parameters were measured in winter and summer. RESULTS A total of 140 subjects completed the study. Significant differences were found in transepidermal water loss (TEWL), skin pH, and cutaneous blood flow (CBF) between winter and summer in the four groups. There were significant differences in stratum corneum hydration (SCH) of the LAST(+)/CAP(-) and LAST(+)/CAP(+) groups, current perception threshold (CPT) at 250 Hz of the LAST(+)/CAT(+) group, and epidermal density of the healthy skin group between the two seasons. Sum of the scores of sting (SSS) showed a close correlation with TEWL, SCH, pH, CPT at 250 Hz, and epidermal density. Sum of the scores of burning (SSB) showed a strong correlation with TEWL, pH, CPT at 250 Hz and 5 Hz, and epidermal density. CONCLUSIONS Seasonal variation influences the skin barrier function of different types of sensitive skin at different levels. We therefore strongly suggest that, with seasonal variation, different treatments will be undertaken for different subgroups of sensitive skin.