Rapid-Acting and Human Insulins: Hexamer Dissociation Kinetics upon Dilution of the Pharmaceutical Formulation

Klaus Gast,Anja Schüler,Martin Wolff,Anja Thalhammer,Harald Berchtold,Norbert Nagel,Gudrun Lenherr,Gerrit Hauck,Robert Seckler

Rapid-Acting and Human Insulins: Hexamer Dissociation Kinetics upon Dilution of the Pharmaceutical Formulation

2017

Klaus Gast
Anja Schüler
Martin Wolff
Anja Thalhammer
Harald Berchtold
Norbert Nagel
Gudrun Lenherr
Gerrit Hauck
Robert Seckler

Purpose Comparison of the dissociation kinetics of rapid-acting insulins lispro, aspart, glulisine and human insulin under physiologically relevant conditions.

Keywords:

Insulin analog
Insulin
Random hexamer
Biochemistry
Pharmaceutical formulation
Circular dichroism
Chemistry
Kinetics
Dilution
Chromatography
dissociation kinetics
human insulin
pharmacology toxicology

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