Serum Pepsinogen Levels as a Screening Test of Gastric Cancer and Adenoma in Korea

To evaluate the validity of serum pepsinogen levels as a screening tool for gastric cancer and adenoma, immunoradiometric assays of serum pepsinogen I level (PG I), II level (PG II) and esphagogastroduodenal endoscopies were done in 757 health examinees. Serum PG I level was higher in subjects with active duodenal ulcer (n=45, , p, p, p. Serum PG II level was higher in subjects with active duodenal ulcer(, p, p, p. Serum PG I/PG II ratio was higher in subjects with active duodenal ulcer(, p, p, p, p, p). Serum PG II level increased with age until 6th decade, whereas serum PG I/PG II ratio decreased with age in 378 subjects with normal, mild gastritis findings or ulcer scars. The screening criteria of serum PG I and PG I/PG II ratio