New phenalenone derivatives from Pinellia ternata tubers derived Aspergillus sp.

Abstract Nine new phenalenone derivatives ( 1 – 9 ), along with two known analogues ( 10  −  11 ) have been isolated from the solid cultures of an endophytic fungus Aspergillus sp. which was obtained from Pinellia ternate . Their structures were established through interpretations of spectroscopic evidence, and some of their absolute configurations were determined by electronic circular dichroism (ECD) and Mo 2 (OCOCH 3 ) 4 induced ECD. All of the phenalenones are unusual acyclic diterpenoid adducts, which are diversely oxidized and partly epoxidized to form different heterocycles. In addition, compound 10 exhibited significant antimicrobial activity against Pseudomonas aeruginosa , Staphylococcus aureus , and Bacillus subtilis with MIC 50 values of 1.87, 2.77, and 4.80 μg/mL, respectively.