The use of biochemical indicators in human saliva for diagnostics periodontitis during pregnancy

The purpose of work - a study of the dynamics of biochemical parameters of human saliva and analysis features of the chemical composition of the saliva of women with abnormal pregnancy and in periodontitis against pregnancy. The study included 4 groups of women: a control group of nonpregnant women of reproductive age (10), pregnant women with physiological pregnancy (24-28 weeks) without any signs of periodontal disease (10), pregnant with a generalized periodontitis I-II degree in remission (10), women with abnormal pregnancy without any signs of periodontal inflammation (10). In each group were collected on two samples of saliva, the first collection of saliva in the morning on an empty stomach. Then assigned mouthwash 0.9% sodium chloride solution and after 30 minutes - the second portion of saliva. In samples of saliva determines the osmolality, the concentration of nitrite, total calcium and inorganic phosphates, as well as the content of the average molecular mass (λ = 254 nm and 280 nm). Established that saliva is a hypo-osmotic fluid, and rinse the mouth 0.9% sodium chloride solution, a group of healthy pregnant women reduces the osmolality of saliva. It is shown that the physiological course of pregnancy is accompanied by a decrease of the contents in the saliva of osmotically active substances, nitrites, and total calcium, and mouthwash 0.9% sodium chloride solution causes no decrease in the concentration of osmotically active substances in saliva. Pathological course of pregnancy, there is no characteristic of the physiological course of pregnancy decrease the value content in the saliva of osmotically active substances and nitrites. In the saliva of pregnant women with periodontitis registered as a high content of nitrites and molecules of average mass, as well as sustained increases in osmolality of saliva in comparison with healthy pregnant women.