Effect of secondary hyperparathyroidism upon serum hydroxyproline in patients with renal failure

: Diagnosis of secondary hyperparathyroidism in 12 patients treated with repeated hemodialysis was established on the basis of clinical symptoms and biochemical studies. Following subtotal parathyroidectomy the resected parathyroid specimens were examined histologically. The diagnostic value of total and free hydroxyproline in the serum in secondary hyperparathyroidism was found to be similar to the diagnostic value of the parathyroid hormone. The correlation with histological diagnosis was from 93% to 100%. After parathyroidectomy a significant decrease in the concentrations of total and free hydroxyproline in the serum was noted being the quickest within the first six months following the resection. The decrease in the concentrations of total and free hydroxyproline in the serum in patients with secondary hyperparathyroidism are valuable diagnostic markers of bone collagen metabolism and bone repair following parathyroidectomy.