BIOPATH - A NEW APPROACH TO FORMALIZED DESCRIPTION AND SIMULATION OF BIOLOGICAL SYSTEMS

SUMMARY Motivation: Reconstruction of complex biological systems from a huge amount of experimental data requires a formal approach for description and simulation of biological pathways on different logical levels. Results: Biopath database was developed for formalized description and simulation of biological systems using two new technologies BioUML and BeanExplorer. All Biopath data can be divided into 4 major blocks: regulation of eukaryotic cell cycle and cancer, NF-κB pathway and inflammation, nucleosomal regulation of gene expression, and human arterial hypertension. Biopath contains links to related biological databases and literature references. It is integrated with Cyclonet database – a specialized database on cell cycle regulation. Availability: http://biopath.biouml.org.