Role of the NLRP3 inflammasome in the transient release of IL-1β induced by monosodium urate crystals in human fibroblast-like synoviocytes

Shucong Zheng,Xiaoxia Zhu,Yu Xue,Li-hong Zhang,Hejian Zou,Jianhua Qiu,Qiong Liu

Role of the NLRP3 inflammasome in the transient release of IL-1β induced by monosodium urate crystals in human fibroblast-like synoviocytes

2015

Shucong Zheng
Xiaoxia Zhu
Yu Xue
Li-hong Zhang
Hejian Zou
Jianhua Qiu
Qiong Liu

Background To investigate whether monosodium urate (MSU) crystals induce interleukin (IL)-1β in human fibroblast-like synoviocytes (FLS), and whether the NLRP3 inflammasome is involved in the inflammatory mechanism.

Keywords:

Molecular medicine
Endocrinology
Inflammasome
Monosodium Urate Crystals
Fibroblast
Internal medicine
Interleukin
Pharmacology
Medicine
Bioinformatics
monosodium urate
pharmacology toxicology
Cell biology

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