Comparison of efficiency and toxicity of two chemotherapy protocols in treatment of advanced non-small cell lung cancer
2011
Introduction. This study was aimed at comparing the efficiency and
tolerability of two reference protocols Cisplatin and Etoposide and Cisplatin
and Vinorelbine in advanced Non-Small Cell Lung Cancer. Material and Methods.
A total of 60 patients (two groups consisting of 30 patients) were treated
for advanced Non-Small Cell Lung Cancer during the period from January to
December 2005 according to the reference protocols (Cisplatin 100mg/m2 D1;
Vinorelbine 30 mg/m2 D1, D8 on 4 weeks) and (Cisplatin 100 mg/m2 D1;
Etoposide 100 mg/m2 D1, D3, D5 on 4 weeks) at the Department of Oncology of
KBC ”Bežanijska kosa”. All patients were analyzed for tumour response,
progression free survival as well as for toxicity. X2 test, Kaplan Meiers
curves and Log rank test were used for statistical analysis. Results.
Although the recorded response rates were a bit lower than in previously
published trials, they were not significantly different p=0.485. No
statistically significant difference was recorded in either progression free
survival or overall survival. The chemotherapeutical Cisplatin/Etoposide
protocol proved to be more toxic both in hematologic (3% vs. 10%) and total
toxicities (p=0.047). Conclusion. Our study proved both protocols to have
equivalent efficacy. However, the Cisplatin, Vinorelbine protocol could be
recommended because of its less expressed toxic effects.
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