Downregulation of miR-27b is Involved in Loss of Type II Collagen by Directly Targeting Matrix Metalloproteinase 13 (MMP13) in Human Intervertebral Disc Degeneration.

Study Design.A microRNA (miRNA) study.Objective.The purpose of this study was to identify intervertebral disc degeneration (IDD)-specific miRNAs, followed by functional validation of results.Summary of Background Data.IDD is the major contributor to back radicular pain, and the molecular mechanisms