Piroxicam sulfonates biology-oriented drug synthesis (BIODS), characterization and anti-nociceptive screening

The present study was designed to synthesize aryl/alkyl sulfonyl substituted derivatives of piroxicam. The structures were elucidated through various spectroscopic procedures like 1H-NMR, 13C-NMR, MS, IR, UV and elemental analysis. The synthesized derivatives (I–VI) were screened for anti-nociceptive activity in BALB-c mice by dividing them in five groups (n = 6) for each compound. Test compounds significantly reduced the number of writhes in acetic acid test for peripheral analgesia, but no effect was observed in hot plate test for central analgesia. The compounds possessed good peripheral analgesic effect but no central effect. These compounds were also assessed for acute toxicity in different doses at 50, 100 and 150 mg/kg i.p., and no mortality was observed in animals. In conclusion, the piroxicam derivatives exhibited marked peripheral anti-nociceptive effect with considerable safety.