A Synthetic Strategy for the Cyclodepsipeptide Core of the Antitumor Antibiotic Verucopeptin.

An efficient [2 + 2 + 2]-fragment condensation strategy is described for obtaining the cyclodepsipeptide core of verucopeptin. The 19-membered macrocycle was established through a Carpino HATU mediated macrolactamization, which proceeded in good yield under high-dilution conditions.