Update on Immune Mechanisms in Systemic Lupus and Lupus Nephritis
2016
Lupus nephritis is a frequent complication of systemic lupus erythematosus. Multiple pathological mechanisms attribute to the pathogenesis of lupus nephritis. These mechanisms can be grossly divided into two groups, extrarenal or intrarenal pathways. A variety of genetic variants break immune tolerance to nuclear autoantigens, as evident from the existence of antinuclear antibodies. Furthermore, molecular mimicry of endogenous nucleic acids activating Toll-like receptors trigger antiviral immunity. In this review, we discuss the molecular pathomechanisms of lupus nephritis.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
52
References
2
Citations
NaN
KQI