Localized osteosclerosis in hyperparathyroidism.

excerpt Roentgenograms showing patchy osteosclerotic changes in the skull in patients with hyperparathyroidism are not frequently seen but certainly are not rare. Osteosclerotic changes involving the lumbar spine and pelvis in cases of either primary or secondary hyperparathyroidism are, however, very unusual. Representative films demonstrating these changes and a brief discussion of possible mechanisms for their occurrence constitute this paper. Characteristic roentgenologic changes of bone mottling, decalcification, cyst formation, and granularity were first associated with hyperparathyroidism by Camp and Ochsner (3) in 1931. Recently Teng and Nathan (7) called attention to the early changes seen in hyperparathyroidism and reviewed the pathognomonic bone signs—subperiosteal and endosteal resorption of bone, subchondral resorption of the clavicle and symphysis pubis, and subperiodontal resorption of the lamina dura. The abnormalities seen in the skull have been discussed by Ellis and Hochstim (5). These ...