The Pathophysiology of Psychosis May Be Nonspecific

Years after Kraepelin differentiated between dementia praecox and manic-depressive insanity, he could no longer tell them apart with certainty. In postmortem brain studies of 15 patients with schizophrenia, 15 with bipolar disorder (11 psychotic), 15 with nonpsychotic unipolar depression, and 15 controls, researchers measured messenger RNA and proteins associated with reelin, glutamic acid decarboxylase67 (GAD67), GAD …