Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice

Highlights •Sinoatrial node (SAN) disease is prevalent in hypertension and heart failure and can be induced by chronic angiotensin II (Ang II) treatment in mice. •Ang II caused SAN disease in mice in association with impaired electrical conduction, reduction in the hyperpolarization-activated current (I f ) in SAN myocytes, and increased SAN fibrosis. •Ang II-induced SAN disease was worsened in mice lacking natriuretic peptide receptor C (NPR-C) in association with enhanced SAN fibrosis. •Mice co-treated with Ang II and an NPR-C agonist (cANF) were protected from SAN disease. •NPR-C may represent a new target to protect against Ang II-induced SAN disease.