Efficient epoxide isomerization within a self-assembled hexameric organic capsule

The isomerization of epoxides to the corresponding carbonyl compounds is efficiently catalyzed by the supramolecular organic nano-capsule formed by the self-assembly of six resorcin[4]arene units. The capsule provides a combination of weak Bronsted acidity and a suitable nano-environment that favors the metal-free isomerization reaction.