Preparation of trans-1,2-diaminocyclohexanetetrachloroplatinum(IV)

718 The complex trans 1,2 diaminocyclohexanetetra chloroplatinum(IV) (ormaplatin, tetraplatin) is a sec ond generation antitumor drug, which is similar in efficiency with respect to various tumors but less nephrotoxic than cis dichlorodiaminoplatinum(II) (cisplatin). It is also efficient against the human and murine tumor cells having the acquired resistance to cisplatin [1]. The preparation of this compound is based on the reactions(1) [2, 3] and (2) [1, 4] where 1,2 Dach is trans 1,2 d,l diaminocyclohexane):