A novel "double-coupling" strategy for iterative oligothiophene synthesis using orthogonal Si/Ge protection.
2002
A new iterative synthesis of regioregular oligothiophenes has been developed in which “double-coupling” after each iteration minimizes deletion sequences. The method exploits the susceptibility of α-silyl- but not α-germyl-substituted thiophene derivatives toward nucleophilic ipso-protodemetalation and features an unusual “base-free” Suzuki-type cross-coupling protocol. The strategy has been designed for the solid-phase synthesis of high purity oligothiophenes using a germanium-based linker.
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