Isolation and Characterization of A Corynebacterium kutscheri Strain in Laboratory Rat

Objective To isolate and identify Corynebacterium kutscheri from rat,and to provide some useful reference for microbiological monitoring in laboratory animal.Method Pathogenic changes of rat was examined.Bacteria cultivation,biological trial,serum agglutination test and animal experiment were carried out.Results Histological examination of C.kutscheri infected rat demonstrated the organism within lung and liver tissues.Isolation and identification of C.kutscheri were performed from laboratory rat which was killed by C.kutscheri infection during a long-term toxicologic study in Beijing.Conclusion The long-term toxicologic study decreased laboratory rat resistance in stressed,which evoked inapparent infection and cause C.kutscheri infected rat dead.We should recognize the importance of C.kutscheri as a potential pathogen in such state.