NEOSYNEPHRIN HYDROCHLORIDE IN OTOLARYNGOLOGY

It is the purpose of this paper to introduce to the otolaryngologist neosynephrin hydrochloride, a new vasoconstrictor which some pharmacologists believe to be superior to epinephrine and ephedrine for local intranasal application. Neosynephrin hydrochloride was accepted by the Council on Pharmacy and Chemistry of the American Medical Association about two years ago and is described in "New and Nonofficial Remedies," yet many otolaryngologists are not familiar with its biologic properties because investigators have reported their experimental and clinical results only in pharmacologic journals. In order to make this paper complete I wish to give, first, a brief resume of the chemistry of the drug and its relationship to other popular vasoconstrictors; second, a review of the previous biologic investigations and a report of the experiments on local intranasal application carried out for purposes of confirmation, and, finally, a resume of fifteen cases, with a summary of