EXPERIMENTAL SURGERY IN ORTHOTOPIC LIVER TRANSPLANTATION (OLTX: ANATOMO-PATHOLOGIC CORRELATION.

The aim of this study is to evaluate retrospectively the liver biopsies in 16 pigs submited to OLTX, at different specific times during the surgery, compare the histological evolution and value the different variates on the complications and on the surgical success. The logist regression test was used as statistic analisis.3 biopsies were practiced in each OLT X:BI: before the ablation; BII: after back table time;BIII:in the revascularised liver. They were histologically cassified in:mild:lesion of hepatocites less then 30%;moderate:30-60% of lesion;and severe:more than 60%. The following variates were correlated with the complications and the surgical success:1)ablation time, 2)fluid volume infusion to the liver, 3)cold isquemic time, 4)back table time, 5)by-pass time, 6)by-pass flow, 7)fluid volume to receptor, 3)medial arterial pressure (M.A.P). BI group showed no lesion (control group)-BII:guidenced mild lesion in 11 cases, moderates in 3, and 2biopsies were not done. BIII:had 11 cases with mild lesion, 4 with moderate and 1 with severe. Mild lesion BII group (11cases) 10 did not suffer changes in their respective BIII and 1 developed on severe BIII, being this one a non primary function(NPF). Moderate lesion BII group did not suffer changes. No necropsy evidenced hepatic lesion as a cause of death, except the NPF succeful transplants (total: 10) 7 were mild lesion. BIII group, and 3 were moderate. Conclusion:There was histological correlation between BII and BIII biopsies, holding on the degree of lesions in 13/14, being the exception a case of NPF, the only cause of hepatic death. The presentation of complications was significant with the by-pass flow(p: 0.03)and M.A.P (p:0.02) and the surgical success with M.A.P(p:0.005), by-pass flow(p:0.001) and fluid volume infused to receptor(p:0.001)