Synthesis and characterization of nano hydroxyapatite powder for drug delivery applications

Nano Hydroxyapatite (HA) particles were prepared by solution combustion method. Effect of various fuel combinations on the reaction condition and powder characteristics were investigated. The powder prepared under optimum condition show crystallite size of 10-20nm, particle size of 100-200nm and surface area of 10-20m2/g. The zeta potential measurements of nano HA powder as a function of pH and addition of dispersant determine the condition of better dispersion in colloidal processing. The sinterability of nano HA was studied in the range of 1200 to 1400C. A study on the use of nano HA for osteoporosis treatment by administering the nano HA loaded residronate sodium (drug) into rats has shown this formulation as a promising targeted drug delivery