In Vivo-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic penA Alleles That Confer Ceftriaxone Resistance in Neisseria gonorrhoeae

Leah R. Vincent,Samuel R. Kerr,Yang Tan,Joshua Tomberg,Erica L. Raterman,Julie C. Dunning Hotopp,Magnus Unemo,Robert A. Nicholas,Ann E. Jerse

In Vivo-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic penA Alleles That Confer Ceftriaxone Resistance in Neisseria gonorrhoeae

2018

Leah R. Vincent
Samuel R. Kerr
Yang Tan
Joshua Tomberg
Erica L. Raterman
Julie C. Dunning Hotopp
Magnus Unemo
Robert A. Nicholas
Ann E. Jerse

Resistance to ceftriaxone in Neisseria gonorrhoeae is mainly conferred by mosaic penA alleles that encode penicillin-binding protein 2 (PBP2) variants with markedly lower rates of acylation by ceft ...

Keywords:

Biology
Genetics
Virology
Neisseria gonorrhoeae
In vivo
Biological fitness
Allele
Antibiotic resistance
Ceftriaxone
Aconitase
Gene
Mutation
Mutant
Strain (chemistry)

Correction
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