Electrospun poly(NVCL-co-AA) fibers as potential thermo-and pH-sensitive agents for controlled release of hydrophobic drugs

2022 
Abstract In this study, poly(N-vinylcaprolactam-co-acrylic acid) (poly(NVCL-co-AA)) containing 20 and 30 mol% AA, were used to prepare thermo-and-pH-sensitive fibers containing a hydrophobic drug, ketoprofen, via electrospinning. Ketoprofen entrapment efficiency was assessed via UV–visible spectroscopy and revealed high values. The interaction drug/copolymer was investigated by FTIR, which indicated the drug entrapment into the fibers. The crystallinity of the ketoprofen-loaded fibers evaluated via DSC confirmed the presence of ketoprofen in its amorphous phase. Cytotoxicity of ketoprofen-loaded fibers was evaluated by cell viability assays using MTT. The results showed that the copolymer was not cytotoxic at a low ketoprofen concentration. The ketoprofen release profile was analyzed using independent and model-dependent approaches and showed slow-release rates at high temperatures. The study of the drug release mechanism showed that the Korsmeyer–Peppas model fits to the release behavior. These findings may expand poly(NVCL-co-AA) application making them promising candidates for temperature and pH responsive drug delivery systems.
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