The lack of damaging effect from sigetin on the development of the reproductive system in rats

Sygethin, an estrogen-like drug, was introduced to rats of the Wistar line during critical periods marking differentiation of hypothalamic sex centers, initial development and differentiation of the mammary glands as well as the time when administration of estrogens caused irreversible changes in the testes. No deviations in the development of test animals similar to those produced by estrogens were disclosed.