Human anti-NR1 autoantibodies induce synaptic pathology with functional relevant loss of postsynaptic NMDA receptors

We investigated the pathogenic role of anti-N-Methyl-D-aspartate receptor (NMDAR) antibodies in neurons and in a mouse model of autoimmune encephalitis using LSM and super-resolution microscopy. We found a functional reduction of synaptic NMDARs.