Implementation of soft microfingers for a hMSC aggregate manipulation system

Small soft ‘fingers’ that safely manipulate cells will ensure the quality and precise control of biological products. The successful progression of regenerative medicine and drug delivery relies on the engineering of lifelike tissues. Specifically, 3D scaffolds provide artificial tissues that reproduce natural processes in the body. However, these fragile biological materials require careful handling — a challenge when using conventional techniques. In their search for precise and gentle alternatives, Satoshi Konishi from Ritsumeikan University and co-workers in Japan generated microscopic polymer-based fingers that pinch and release cell aggregates without damage. The fingers comprise two bonded pneumatic balloons that act as synthetic muscles. Normally closed, their extremities open when the balloons are inflated. Combined with a microscope and a 3D positioning system, the fingers can pick up the aggregates and transfer them to a specific location.